A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial.
Identifieur interne : 004387 ( Main/Exploration ); précédent : 004386; suivant : 004388A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial.
Auteurs : Eileen M. Bulger [États-Unis] ; Ronald V. Maier [États-Unis] ; Jason Sperry [États-Unis] ; Manjari Joshi [États-Unis] ; Sharon Henry [États-Unis] ; Frederick A. Moore ; Lyle L. Moldawer ; Demetrios Demetriades [États-Unis] ; Peep Talving [États-Unis] ; Martin Schreiber [États-Unis] ; Bruce Ham [États-Unis] ; Mitchell Cohen [États-Unis] ; Steven Opal [États-Unis] ; Irit Segalovich [Israël] ; Greg Maislin [États-Unis] ; Raymond Kaempfer [Israël] ; Anat Shirvan [Israël]Source :
- JAMA surgery [ 2168-6262 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antigène CD28 (administration et posologie), Antigène CD28 (usage thérapeutique), Cytokines (analyse), Débridement, Femelle, Humains, Infections des tissus mous (traitement médicamenteux), Injections veineuses, Mâle, Méthode en double aveugle, Nécrose, Placebo, Résultat thérapeutique, Scores de dysfonction d'organes, Sujet âgé, Sujet âgé de 80 ans ou plus, États-Unis d'Amérique, Études prospectives.
- MESH :
- administration et posologie : Antigène CD28.
- analyse : Cytokines.
- traitement médicamenteux : Infections des tissus mous.
- usage thérapeutique : Antigène CD28.
- Adulte, Adulte d'âge moyen, Débridement, Femelle, Humains, Injections veineuses, Mâle, Méthode en double aveugle, Nécrose, Placebo, Résultat thérapeutique, Scores de dysfonction d'organes, Sujet âgé, Sujet âgé de 80 ans ou plus, États-Unis d'Amérique, Études prospectives.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antigens, CD28 (administration & dosage), Antigens, CD28 (therapeutic use), Cytokines (analysis), Debridement, Double-Blind Method, Female, Humans, Injections, Intravenous, Male, Middle Aged, Necrosis, Organ Dysfunction Scores, Placebos, Prospective Studies, Soft Tissue Infections (drug therapy), Treatment Outcome, United States.
- MESH :
- chemical , administration & dosage : Antigens, CD28.
- chemical , analysis : Cytokines.
- chemical , therapeutic use : Antigens, CD28.
- geographic : United States.
- drug therapy : Soft Tissue Infections.
- Adult, Aged, Aged, 80 and over, Debridement, Double-Blind Method, Female, Humans, Injections, Intravenous, Male, Middle Aged, Necrosis, Organ Dysfunction Scores, Placebos, Prospective Studies, Treatment Outcome.
Abstract
Necrotizing soft-tissue infections (NSTI) have high morbidity and mortality rates despite aggressive surgical debridement and antibiotic therapy. AB103 is a peptide mimetic of the T-lymphocyte receptor, CD28. We hypothesized that AB103 will limit inflammatory responses to bacterial toxins and decrease the incidence of organ failure.
DOI: 10.1001/jamasurg.2013.4841
PubMed: 24740134
Affiliations:
- Israël, États-Unis
- Californie, Maryland, Oregon, Pennsylvanie, Rhode Island, Washington (État)
- Baltimore, Los Angeles, Portland, San Francisco, Seattle
- Université de Washington
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Le document en format XML
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Bulger</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, Harborview Medical Center, University of Washington, Seattle.</nlm:affiliation><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Maier, Ronald V" sort="Maier, Ronald V" uniqKey="Maier R" first="Ronald V" last="Maier">Ronald V. Maier</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, Harborview Medical Center, University of Washington, Seattle.</nlm:affiliation><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Sperry, Jason" sort="Sperry, Jason" uniqKey="Sperry J" first="Jason" last="Sperry">Jason Sperry</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Joshi, Manjari" sort="Joshi, Manjari" uniqKey="Joshi M" first="Manjari" last="Joshi">Manjari Joshi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery and Medicine, University of Maryland, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Department of Surgery and Medicine, University of Maryland</wicri:orgArea></affiliation></author><author><name sortKey="Henry, Sharon" sort="Henry, Sharon" uniqKey="Henry S" first="Sharon" last="Henry">Sharon Henry</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery and Medicine, University of Maryland, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Department of Surgery and Medicine, University of Maryland</wicri:orgArea></affiliation></author><author><name sortKey="Moore, Frederick A" sort="Moore, Frederick A" uniqKey="Moore F" first="Frederick A" last="Moore">Frederick A. Moore</name><affiliation><nlm:affiliation>Department of Surgery, University of Florida, Gainesville.</nlm:affiliation><wicri:noCountry code="subField">Gainesville</wicri:noCountry></affiliation></author><author><name sortKey="Moldawer, Lyle L" sort="Moldawer, Lyle L" uniqKey="Moldawer L" first="Lyle L" last="Moldawer">Lyle L. Moldawer</name><affiliation><nlm:affiliation>Department of Surgery, University of Florida, Gainesville.</nlm:affiliation><wicri:noCountry code="subField">Gainesville</wicri:noCountry></affiliation></author><author><name sortKey="Demetriades, Demetrios" sort="Demetriades, Demetrios" uniqKey="Demetriades D" first="Demetrios" last="Demetriades">Demetrios Demetriades</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, University of Southern California, Los Angeles.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Surgery, University of Southern California</wicri:orgArea></affiliation></author><author><name sortKey="Talving, Peep" sort="Talving, Peep" uniqKey="Talving P" first="Peep" last="Talving">Peep Talving</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, University of Southern California, Los Angeles.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Surgery, University of Southern California</wicri:orgArea></affiliation></author><author><name sortKey="Schreiber, Martin" sort="Schreiber, Martin" uniqKey="Schreiber M" first="Martin" last="Schreiber">Martin Schreiber</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Oregon Health & Science University, Portland.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Portland</settlement><region type="state">Oregon</region></placeName><wicri:orgArea>Department of Surgery, Oregon Health & Science University</wicri:orgArea></affiliation></author><author><name sortKey="Ham, Bruce" sort="Ham, Bruce" uniqKey="Ham B" first="Bruce" last="Ham">Bruce Ham</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, Oregon Health & Science University, Portland.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Portland</settlement><region type="state">Oregon</region></placeName><wicri:orgArea>Department of Surgery, Oregon Health & Science University</wicri:orgArea></affiliation></author><author><name sortKey="Cohen, Mitchell" sort="Cohen, Mitchell" uniqKey="Cohen M" first="Mitchell" last="Cohen">Mitchell Cohen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgery, University of California, San Francisco.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Surgery, University of California</wicri:orgArea></affiliation></author><author><name sortKey="Opal, Steven" sort="Opal, Steven" uniqKey="Opal S" first="Steven" last="Opal">Steven Opal</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Medicine, Alpert Medical School of Brown University, Providence</wicri:cityArea></affiliation></author><author><name sortKey="Segalovich, Irit" sort="Segalovich, Irit" uniqKey="Segalovich I" first="Irit" last="Segalovich">Irit Segalovich</name><affiliation wicri:level="1"><nlm:affiliation>Atox Bio Ltd, Ness Ziona, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Atox Bio Ltd, Ness Ziona</wicri:regionArea><wicri:noRegion>Ness Ziona</wicri:noRegion></affiliation></author><author><name sortKey="Maislin, Greg" sort="Maislin, Greg" uniqKey="Maislin G" first="Greg" last="Maislin">Greg Maislin</name><affiliation wicri:level="2"><nlm:affiliation>Biomedical Statistical Consulting, Wynnewood, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Biomedical Statistical Consulting, Wynnewood</wicri:cityArea></affiliation></author><author><name sortKey="Kaempfer, Raymond" sort="Kaempfer, Raymond" uniqKey="Kaempfer R" first="Raymond" last="Kaempfer">Raymond Kaempfer</name><affiliation wicri:level="1"><nlm:affiliation>Atox Bio Ltd, Ness Ziona, Israel11Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Atox Bio Ltd, Ness Ziona, Israel11Department of Molecular Biology, Hebrew University Hadassah Medical School, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Shirvan, Anat" sort="Shirvan, Anat" uniqKey="Shirvan A" first="Anat" last="Shirvan">Anat Shirvan</name><affiliation wicri:level="1"><nlm:affiliation>Atox Bio Ltd, Ness Ziona, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Atox Bio Ltd, Ness Ziona</wicri:regionArea><wicri:noRegion>Ness Ziona</wicri:noRegion></affiliation></author></analytic><series><title level="j">JAMA surgery</title><idno type="eISSN">2168-6262</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antigens, CD28 (administration & dosage)</term><term>Antigens, CD28 (therapeutic use)</term><term>Cytokines (analysis)</term><term>Debridement</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Middle Aged</term><term>Necrosis</term><term>Organ Dysfunction Scores</term><term>Placebos</term><term>Prospective Studies</term><term>Soft Tissue Infections (drug therapy)</term><term>Treatment Outcome</term><term>United States</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigène CD28 (administration et posologie)</term><term>Antigène CD28 (usage thérapeutique)</term><term>Cytokines (analyse)</term><term>Débridement</term><term>Femelle</term><term>Humains</term><term>Infections des tissus mous (traitement médicamenteux)</term><term>Injections veineuses</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Nécrose</term><term>Placebo</term><term>Résultat thérapeutique</term><term>Scores de dysfonction d'organes</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>États-Unis d'Amérique</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antigens, CD28</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antigens, CD28</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antigène CD28</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Soft Tissue Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections des tissus mous</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antigène CD28</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Debridement</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Injections, Intravenous</term><term>Male</term><term>Middle Aged</term><term>Necrosis</term><term>Organ Dysfunction Scores</term><term>Placebos</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Débridement</term><term>Femelle</term><term>Humains</term><term>Injections veineuses</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Nécrose</term><term>Placebo</term><term>Résultat thérapeutique</term><term>Scores de dysfonction d'organes</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>États-Unis d'Amérique</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Necrotizing soft-tissue infections (NSTI) have high morbidity and mortality rates despite aggressive surgical debridement and antibiotic therapy. AB103 is a peptide mimetic of the T-lymphocyte receptor, CD28. We hypothesized that AB103 will limit inflammatory responses to bacterial toxins and decrease the incidence of organ failure.</div></front></TEI><affiliations><list><country><li>Israël</li><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li><li>Oregon</li><li>Pennsylvanie</li><li>Rhode Island</li><li>Washington (État)</li></region><settlement><li>Baltimore</li><li>Los Angeles</li><li>Portland</li><li>San Francisco</li><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Moldawer, Lyle L" sort="Moldawer, Lyle L" uniqKey="Moldawer L" first="Lyle L" last="Moldawer">Lyle L. Moldawer</name><name sortKey="Moore, Frederick A" sort="Moore, Frederick A" uniqKey="Moore F" first="Frederick A" last="Moore">Frederick A. Moore</name></noCountry><country name="États-Unis"><region name="Washington (État)"><name sortKey="Bulger, Eileen M" sort="Bulger, Eileen M" uniqKey="Bulger E" first="Eileen M" last="Bulger">Eileen M. Bulger</name></region><name sortKey="Cohen, Mitchell" sort="Cohen, Mitchell" uniqKey="Cohen M" first="Mitchell" last="Cohen">Mitchell Cohen</name><name sortKey="Demetriades, Demetrios" sort="Demetriades, Demetrios" uniqKey="Demetriades D" first="Demetrios" last="Demetriades">Demetrios Demetriades</name><name sortKey="Ham, Bruce" sort="Ham, Bruce" uniqKey="Ham B" first="Bruce" last="Ham">Bruce Ham</name><name sortKey="Henry, Sharon" sort="Henry, Sharon" uniqKey="Henry S" first="Sharon" last="Henry">Sharon Henry</name><name sortKey="Joshi, Manjari" sort="Joshi, Manjari" uniqKey="Joshi M" first="Manjari" last="Joshi">Manjari Joshi</name><name sortKey="Maier, Ronald V" sort="Maier, Ronald V" uniqKey="Maier R" first="Ronald V" last="Maier">Ronald V. Maier</name><name sortKey="Maislin, Greg" sort="Maislin, Greg" uniqKey="Maislin G" first="Greg" last="Maislin">Greg Maislin</name><name sortKey="Opal, Steven" sort="Opal, Steven" uniqKey="Opal S" first="Steven" last="Opal">Steven Opal</name><name sortKey="Schreiber, Martin" sort="Schreiber, Martin" uniqKey="Schreiber M" first="Martin" last="Schreiber">Martin Schreiber</name><name sortKey="Sperry, Jason" sort="Sperry, Jason" uniqKey="Sperry J" first="Jason" last="Sperry">Jason Sperry</name><name sortKey="Talving, Peep" sort="Talving, Peep" uniqKey="Talving P" first="Peep" last="Talving">Peep Talving</name></country><country name="Israël"><noRegion><name sortKey="Segalovich, Irit" sort="Segalovich, Irit" uniqKey="Segalovich I" first="Irit" last="Segalovich">Irit Segalovich</name></noRegion><name sortKey="Kaempfer, Raymond" sort="Kaempfer, Raymond" uniqKey="Kaempfer R" first="Raymond" last="Kaempfer">Raymond Kaempfer</name><name sortKey="Shirvan, Anat" sort="Shirvan, Anat" uniqKey="Shirvan A" first="Anat" last="Shirvan">Anat Shirvan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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